Site‐specific recombination events are of fundamental importance in many biological systems. In vitro experiments using purified proteins and DNA sub‐strates are yielding insights into strand exchange mechanisms and synapsis of recombination sites. By examining results across a range of systems ‐ prokaryotic and eukaryotic ‐ two distinct classes of site‐specific recombinase enzymes can be defined.

Avant-propos.--Notes: Y a-t-il eu un "avicennisme latin"? Guillaume d'Auvergne témoin de l'"Avicennisme latin." Avicenne et les décrets de 1210 et 1215. Un témoignage de Guillaume d'Auxerre. Un texte d'Albert le Grand. Le cas de Roger Bacon. La date, les sources et la doctrine du "Liber de causis primis et secundis."--Textes: Le "Liber de causis primis et secundis." La fin du "De anima" de Gundissalinus. Tables.

Blood service organizations employ various ways to ensure transfusion blood safety, including the testing of all donations for transfusion-transmissible infections (TTI) and the exclusion of donors who are at increased risk of a recent infection. As some TTIs are more common among men who have sex with men (MSM), many jurisdictions (temporarily) defer the donation of blood by sexually active MSM. This boils down to a categorical exclusion of a large group solely on the basis of their sexual orientation, which (...) is seen as unduly discriminatory and stigmatizing. Blood service organizations in the U.K. and the Netherlands have recently changed their deferral policies for MSM. The problem of the MSM deferral involves a conflict between fundamental rights: the right of MSM to equal treatment and the right to health of the recipients of blood and blood products. We distinguish and discuss three broad alternative options to the current categorical deferral of MSM donations: (1) completely abandoning donor selection on the basis of sexual behavior, (2) individual risk assessment of the sexual activities of each potential donor, and (3) individual risk assessment of the sexual activities of MSM only. The new U.K. policy falls within the second category, and the new Dutch policy is in the third category. We argue that each approach comes with moral costs but that the most reasonable option is different from the policies of both the U.K. and the Netherlands. (shrink)

Dementia is highly prevalent and incurable. The participation of dementia patients in clinical research is indispensable if we want to find an effective treatment for dementia. However, one of the primary challenges in dementia research is the patients’ gradual loss of the capacity to consent. Patients with dementia are characterized by the fact that, at an earlier stage of their life, they were able to give their consent to participation in research. Therefore, the phase when patients are still competent to (...) decide offers a valuable opportunity to authorize research, by using an advance research directive. Yet, the use of ARDs as an authorization for research participation remains controversial. In this paper we discuss the role of autonomous decision-making and the protection of incompetent research subjects. We will show why ARDs are a morally defensible basis for the inclusion of this population in biomedical research and that the use of ARDs is compatible with the protection of incompetent research subjects. (shrink)

Theory suggests that stimulus evaluations automatically evoke approach–avoidance behavior. However, the extent to which approach–avoidance behavior is triggered automatically is not yet clear. Furthermore, the nature of automatically triggered approach–avoidance behavior is controversial. We review research on two views on the type of approach–avoidance behavior that is triggered automatically (arm flexion/extension, distance change). Present evidence supports the distance-change view and corroborates the notion of an automatic pathway from evaluation to distance-change behavior. We discuss underlying mechanisms (direct stimulus–response links, outcome anticipations, (...) goals) as well as implications regarding the flexibility of the evaluation–behavior link. (shrink)

Abstract In the present article, we provide a critical overview of the emerging field of ‘neuroeducation’ also frequently referred to as ‘mind, brain and education’ or ‘educational neuroscience’. We describe the growing energy behind linking education and neuroscience in an effort to improve learning and instruction. We explore reasons behind such drives for interdisciplinary research. Reviewing some of the key advances in neuroscientific studies that have come to bear on neuroeducation, we discuss recent evidence on the brain circuits underlying reading, (...) mathematical abilities as well as the potential to use neuroscience to design training programs of neurocognitive functions, such as working memory, that are expected to have effects on overall brain function. Throughout this review we describe how such research can enrich our understanding of the acquisition of academic skills. Furthermore, we discuss the potential for modern brain imaging methods to serve as diagnostic tools as well as measures of the effects of educational interventions. Throughout this discussion, we draw attention to limitations of the available evidence and propose future avenues for research. We also discuss the challenges that face this growing discipline. Specifically, we draw attention to unrealistic expectations for the immediate impact of neuroscience on education, methodological difficulties, and lack of interdisciplinary training, which results in poor communication between educators and neuroscientists. We point out that there should be bi-directional and reciprocal interactions between both disciplines of neuroscience and education, in which research originating from each of these traditions is considered to be compelling in its own right. While there are many obstacles that lie in the way of a productive field of neuroeducation, we contend that there is much reason to be optimistic and that the groundwork has been laid to advance this field in earnest. Content Type Journal Article Category Original Paper Pages 1-13 DOI 10.1007/s12152-011-9119-3 Authors Daniel Ansari, Numerical Cognition Laboratory, Department of Psychology, The University of Western Ontario, Westminster Hall, London, ON N6A 3K7, Canada Bert De Smedt, Parenting and Special Education Research Group, Katholieke Universiteit Leuven, Leuven, Belgium Roland H. Grabner, Institute for Behavioral Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland Journal Neuroethics Online ISSN 1874-5504 Print ISSN 1874-5490. (shrink)

Serious incident investigations—often conducted by means of Root Cause Analysis methodologies—are increasingly seen as platforms to learn from multiple perspectives and experiences: professionals, patients and their families alike. Underlying this principle of inclusiveness is the idea that healthcare staff and service users hold unique and valuable knowledge that can inform learning, as well as the notion that learning is a social process that involves people actively reflecting on shared knowledge. Despite initiatives to facilitate inclusiveness, research shows that embracing and learning (...) from diverse perspectives is difficult. Using the concept of ‘epistemic injustice’, pointing at practices of someone’s knowledge being unjustly disqualified or devalued, we analyze the way incident investigations are organized and executed with the aim to understand why it is difficult to embrace and learn from the multiple perspectives voiced in incident investigations. We draw from 73 semi-structured interviews with healthcare leaders, managers, healthcare professionals, incident investigators and inspectors, document analyses and ethnographic observations. Our analysis identified several structures in the incident investigation process, that can promote or hinder an actor’s epistemic contribution in the process of incident investigations. Rather than repeat calls to ‘involve more’ and ‘listen better’, we encourage policy makers to be mindful of and address the structures that can cause epistemic injustice. This can improve the outcome of incident investigations and can help to do justice to the lived experiences of the involved actors in the aftermath of a serious incident. (shrink)

This article’s aim is to understand if and how the efforts to accumulate and organize clinical data transformed the regulation of pharmaceutical care. The authors analyze how the employment of databases by collectives of physicians and researchers shape both clinical and policy practice—and thereby reshape the relation between clinical work and policy. Since the late 1990s, Dutch government has supported the development of clinical databases for specific expensive medicines to gain oversight about actual medicine use. To be able to produce (...) evidence for appropriate medicine use, the collectives set regulations in clinical practice. These internal regulations provide a framework for establishing “appropriate medicine use”, steering reimbursement decisions. However, internal regulation and policy rules differ in how quickly they can change. While the employment of databases in clinical practices results in a constant adjustment of the protocols, policy makers require the databases to provide for static moments of “proven appropriate medicine use” in order to account for and define a fixed and closed formulary. Subsequently, the employment of the databases did not deliver on the promise of oversight and control due to different clinical and policy requirements. Nevertheless, the databases did stimulate appropriate medicine use and reimbursement in clinical practice. (shrink)

Une approche philosophique de la prière à des fins politiques est possible dans le cas où les deux substantifs sont mis en relais inconditionnel. Le premier élément responsable de cette filature des liens c’est la présence de l’autre. Prier et faire de la politique sont deux activités humaines trop humaines qui exigent l’ouverture à l’autre, pour l’autre comme pour l’édification de sa propre identité individuelle et collective. Comme les rites et les cultes, la liturgie, notamment la prière collective, a un (...) effet thérapeutique, et pédagogique, disons didactique et sociopolitique. Elle calme les esprits, la volonté, apaise l’angoisse et solidifie les liens sociaux. L'Eglise, par exemple, est née du rassemblement du peuple de Dieu en prière et c'est dans son sein que toute célébration liturgique trouve perpétuellement son accomplissement aussi bien que sa régénération dans l’invocation du nom du Christ-Vérité, Rédempteur, Fondateur, Roi et Prêtre. La présente étude sur « Vérité et Royauté » focalise l’attention sur l’essence même du politique qui se nourrit du religieux tout en lui fournissant gloire, pouvoir et moyens d’existence. (shrink)

"I define the Neutral as that which outplays the paradigm, or rather I call Neutral everything that baffles paradigm." With these words, Roland Barthes describes a concept that profoundly shaped his work and was the subject of a landmark series of lectures delivered in 1978 at the Collège de France, just two years before his death. Not published in France until 2002, and appearing in English for the first time, these creative and engaging lectures deepen our understanding of (...) class='Hi'>Roland Barthes's intellectual itinerary and reveal his distinctive style as thinker and teacher. The Neutral (_le neutre_), as Barthes describes it, escapes or undoes the paradigmatic binary oppositions that structure and produce meaning in Western thought and discourse. These binaries are found in all aspects of human society ranging from language to sexuality to politics. For Barthes, the attempt to deconstruct or escape from these binaries has profound ethical, philosophical, and linguistic implications. _The Neutral_ is comprised of the prewritten texts from which Barthes lectured and centers around 23 "figures," also referred to as "traits" or "twinklings," that are possible embodiments of the Neutral (sleep, silence, tact, etc.) or of the anti-Neutral (anger, arrogance, conflict, etc.). His lectures draw on a diverse set of authors and intellectual traditions, including Lao-tzu, Tolstoy, German mysticism, classical philosophy, Rousseau, Baudelaire, Walter Benjamin, and John Cage. Barthes's idiosyncratic approach to his subjects gives the lectures a playful, personal, and even joyous quality that enhances his rich insights. In addition to his reflections on a variety of literary and scholarly works, Barthes's personal convictions and the events of his life shaped the course and content of the lectures. Most prominently, as Barthes admits, the recent death of his mother and the idea of mourning shape several of his lectures. (shrink)

We would like to conduct a phenomenological analysis of illness beyond the characteristics which define it scientifically, in order to consider the suffering experience of the sick person which, in reality, constitute its authentic truth. Following Michel Henry’s philosophy which defines life as pathetic self-affection, we will understand that illness may and must first of all be considered as an intense form of this unsurmountable link to one’s self which concerns the very essence of everyone of us as a living (...) ipseity. Then, if “One does not feel”, if suffering is always a founding individual experience, the principle that medicine should be attentive to the subjective experience of patients is consequently established. Then we can also begin to understand the enigma of a patient’s attachment to his illness, to the point of refusing to be cured, as an inappropriate existential expression of an ontological fear of losing oneself. (shrink)

Supposons qu'il soit possible de transplanter les centres de Ia douleur de Jones dans le cerveau de Smith. A mi-chemin pendant!'operation, on teste ces centres de Ia douleur en les stimulant électriquement in vitro. Y aurait-il de Ia douleur? L'argument de cet article est qu'il n'y en aurait pas, parce que Ia douleur doit avoir un possesseur. Sinon, il ne peut arriver que les centres de Ia douleur se déchargeant dans un cerveau soient en eux-mêmes Ia douleur. On peut logiquement (...) transférer le mécanisms de Ia douleur, mais non Ia douleur elle-mêmes. Ainsi le materialisme est faux.Suppose we live in a very advanced age of neurosurgical skills. We have a patient, Jones, with intractable pain. We have a second patient, Smith, with a long history of unintentional self-injury due to congenital absence of pain centres. So we decide to do double service by transplanting Jones's pain centres into Smith's brain. (shrink)

Definition of the problem: Contemporary bioethics as an academic discipline mainly focuses on moral questions – according to its articulated self-concept and the explicit arguments in most areas of bioethical reflection. Concepts and theories of the good life are hardly considered. Arguments: In reality the ‘good life’ plays a much more important role than it is assumed, but mostly only in an implicit way. The article demonstrates this by referencing three selected fields of bioethical discussion. Hence the article argues that (...) bioethics should turn the ‘good life’ into an issue of intense, explicit and systematic consideration. Furthermore, the article provides an initial answer to the questions as to why the ‘good life’ has been marginalized within bioethics up to this point and which function it can assume in future bioethical reflection. Conclusion: The ‘good life’ is the blind spot of bioethics. A more intensive and systematic consideration of the ‘good life’ is a challenge for contemporary and future bioethics. (shrink)

Supposons qu'il soit possible de transplanter les centres de Ia douleur de Jones dans le cerveau de Smith. A mi-chemin pendant!'operation, on teste ces centres de Ia douleur en les stimulant électriquement in vitro. Y aurait-il de Ia douleur? L'argument de cet article est qu'il n'y en aurait pas, parce que Ia douleur doit avoir un possesseur. Sinon, il ne peut arriver que les centres de Ia douleur se déchargeant dans un cerveau soient en eux-mêmes Ia douleur. On peut logiquement (...) transférer le mécanisms de Ia douleur, mais non Ia douleur elle-mêmes. Ainsi le materialisme est faux.Suppose we live in a very advanced age of neurosurgical skills. We have a patient, Jones, with intractable pain. We have a second patient, Smith, with a long history of unintentional self-injury due to congenital absence of pain centres. So we decide to do double service by transplanting Jones's pain centres into Smith's brain. (shrink)

Ce recueil témoigne d'un double ancrage : dans la phénoménologie de la vie de Michel Henry et dans la tradition zen. En confrontant ces deux pensées, il montre la fécondité d'une mise en relation de deux approches philosophiques radicales de la réalité humaine sise dans la vie qui la porte et constitue son origine absolue. L'auteur lit chez Michel Henry, dont il fut l'élève et l'ami, les catégories capables d'établir une lecture croisée entre deux formes d'exploration rigoureuses de la subjectivité.

Après un premier volume, A l'Orient de Michel Henry (2014), cet ensemble de textes poursuit la quête d'une définition de la vérité comprise comme subjectivité vivante, comme cette épreuve de soi qui conditionne et transite ensuite l'ensemble des expériences et des savoirs qui sont les nôtres. Il apparaîtra, ce faisant, le caractère éminemment concret des catégories mises en oeuvre par Michel Henry et comment elles peuvent s'appliquer à de nombreux domaines d'existence, étant capables d'en rendre compte avec cette pertinence et (...) cette puissance explicative que permet seul leur ancrage dans le fondement vivant qui les informe secrètement sous l'apparence des choses. (shrink)

Kant a montré plusieurs fois sa position vis-à-vis des révolutions de son temps et de toute révolution en général. En quoi sa réflexion peut-elle nous éclairer? La réponse en surprendra plus d'un, d'autant que Kant apparaît d'ordinaire comme un réformateur. Sous quelles conditions un droit de révolution est-il pensable? L'est-il dans son rapport à la légalité? Sinon, est-il envisageable en dehors de ce rapport? Mais alors sur quelle instance rationnelle faut-il le fonder? Pour Kant, la finalité de l'histoire universelle repose (...) sur un jugement certain, une histoire qui utilise tous les moyens dont elle dispose pour parvenir à une meilleure fin possible, quoique non définitive. Parmi ces moyens, peut-être la révolution! (shrink)

Analyse: Contient un chapitre sur Francis Giauque et une évocation de Henri-Frédéric Amiel.

"Il n'y a pas de philosophie de Wittgenstein. Il y a l'histoire d'un homme qui lutta pied à pied contre la folie et le suicide avec pour seules armes la logique et l'éthique. Cet homme, on l'a dépeint tantôt comme un monstre, tantôt comme un saint, tantôt comme un génie, tantôt comme un détraqué sexuel. A Vienne où il a passé sa jeunesse, comme à Cambridge où il a enseigné, il est vite devenu une légende. Les rumeurs les plus extravagantes (...) ont circulé sur son compte : on prétendit même que sa grande oeuvre n'était pas le "Tractacus logico-philosophicus" mais le suicide de son ancien camarade de classe Adolf Hitler et de sa compagne, Eva Braun, dans leur bunker berlinois. Ce qui demeure certain, c'est qu'aucun philosophe n'aura mené avec un tel acharnement son enquête sur "le monde tel qu'il l'a trouvé", ni sur les fins ultimes de l'existence. Dans ce bref essai, R. J. tente "à la manière de Stefan Zweig parlant de Montaigne, de Nietzsche, de Freud, " de cerner la personnalité de Wittgenstein et de faire quelques pas en sa compagnie.". (shrink)

L'interrogation du phénomène esthétique est contemporaine de l'autonomisation de l'art au cours des Temps modernes et de la relativisation de sa fonction lorsqu'il n'est plus que le moyen d'exprimer la vie émotionnelle subjective. En revanche, lorsque la singularité même de l'œuvre d'art se voit mise en question au XXe siècle, ce sont les frontières séparant l'art du non-art qui deviennent évanescentes. C'est sur le fond de cet évènement que s'est déployée la réflexion de Roland Quilliot, que les contributions de (...) ce recueil se proposent de poursuivre. Celles-ci reviennent sur la notion d'image puis sur la manière dont elle se déploie du côté de la littérature comme des arts plastiques y compris du cinéma. Le second temps du recueil s'inscrit, lui, dans le cadre d'une réflexion relative à la crise de l'art moderne, en suggérant aussi que le phénomène esthétique demande à être considéré dans un cadre moral et anthropologique bien plus englobant. (shrink)

Au nom d'un "rationalisme économique morbide" une nouvelle colonisation des esprits envahit la planète. Avec ses agences d'évaluation et ses hommes de main, cette "religion du marché" interdit de penser le monde, notre monde, autrement que comme un stock de marchandises ou de produits financiers. Pour réaliser cette nouvelle manière de civiliser les moeurs il fallait faire chuter la valeur de l'expérience et celle du récit - de la parole - qui la transmet. En faisant baisser le cours de la (...) parole au profit de l'information, de sa part la plus technique et mesurable, nous perdons le monde commun, nous perdons notre monde. Et plus encore en Occident, nous nous habituons à lâcher la démocratie pour l'ombre d'une technocratie qui organise insidieusement nos servitudes volontaires. Cet ouvrage invite au retour du politique pour retrouver les conditions sociales et culturelles permettant de penser, de juger et de décider. Cela exige que soit d'abord interrogé le statut du savoir dans la culture, son rapport à l'expérience et aux pratiques sociales. Mais comment retrouver aujourd'hui la dignité de penser dans une culture qui ignore la légitimité du savoir du conte, du rêve, du jeu et de leurs récits? La France qui se lève tôt a-t-elle encore le temps de raconter sa vie, son histoire et ses rêves? (shrink)