Abstract In the present article, we provide a critical overview of the emerging field of ‘neuroeducation’ also frequently referred to as ‘mind, brain and education’ or ‘educational neuroscience’. We describe the growing energy behind linking education and neuroscience in an effort to improve learning and instruction. We explore reasons behind such drives for interdisciplinary research. Reviewing some of the key advances in neuroscientific studies that have come to bear on neuroeducation, we discuss recent evidence on the brain circuits underlying reading, (...) mathematical abilities as well as the potential to use neuroscience to design training programs of neurocognitive functions, such as working memory, that are expected to have effects on overall brain function. Throughout this review we describe how such research can enrich our understanding of the acquisition of academic skills. Furthermore, we discuss the potential for modern brain imaging methods to serve as diagnostic tools as well as measures of the effects of educational interventions. Throughout this discussion, we draw attention to limitations of the available evidence and propose future avenues for research. We also discuss the challenges that face this growing discipline. Specifically, we draw attention to unrealistic expectations for the immediate impact of neuroscience on education, methodological difficulties, and lack of interdisciplinary training, which results in poor communication between educators and neuroscientists. We point out that there should be bi-directional and reciprocal interactions between both disciplines of neuroscience and education, in which research originating from each of these traditions is considered to be compelling in its own right. While there are many obstacles that lie in the way of a productive field of neuroeducation, we contend that there is much reason to be optimistic and that the groundwork has been laid to advance this field in earnest. Content Type Journal Article Category Original Paper Pages 1-13 DOI 10.1007/s12152-011-9119-3 Authors Daniel Ansari, Numerical Cognition Laboratory, Department of Psychology, The University of Western Ontario, Westminster Hall, London, ON N6A 3K7, Canada Bert De Smedt, Parenting and Special Education Research Group, Katholieke Universiteit Leuven, Leuven, Belgium Roland H. Grabner, Institute for Behavioral Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland Journal Neuroethics Online ISSN 1874-5504 Print ISSN 1874-5490. (shrink)

Dementia is highly prevalent and incurable. The participation of dementia patients in clinical research is indispensable if we want to find an effective treatment for dementia. However, one of the primary challenges in dementia research is the patients’ gradual loss of the capacity to consent. Patients with dementia are characterized by the fact that, at an earlier stage of their life, they were able to give their consent to participation in research. Therefore, the phase when patients are still competent to (...) decide offers a valuable opportunity to authorize research, by using an advance research directive. Yet, the use of ARDs as an authorization for research participation remains controversial. In this paper we discuss the role of autonomous decision-making and the protection of incompetent research subjects. We will show why ARDs are a morally defensible basis for the inclusion of this population in biomedical research and that the use of ARDs is compatible with the protection of incompetent research subjects. (shrink)

Site‐specific recombination events are of fundamental importance in many biological systems. In vitro experiments using purified proteins and DNA sub‐strates are yielding insights into strand exchange mechanisms and synapsis of recombination sites. By examining results across a range of systems ‐ prokaryotic and eukaryotic ‐ two distinct classes of site‐specific recombinase enzymes can be defined.

Avant-propos.--Notes: Y a-t-il eu un "avicennisme latin"? Guillaume d'Auvergne témoin de l'"Avicennisme latin." Avicenne et les décrets de 1210 et 1215. Un témoignage de Guillaume d'Auxerre. Un texte d'Albert le Grand. Le cas de Roger Bacon. La date, les sources et la doctrine du "Liber de causis primis et secundis."--Textes: Le "Liber de causis primis et secundis." La fin du "De anima" de Gundissalinus. Tables.

Blood service organizations employ various ways to ensure transfusion blood safety, including the testing of all donations for transfusion-transmissible infections (TTI) and the exclusion of donors who are at increased risk of a recent infection. As some TTIs are more common among men who have sex with men (MSM), many jurisdictions (temporarily) defer the donation of blood by sexually active MSM. This boils down to a categorical exclusion of a large group solely on the basis of their sexual orientation, which (...) is seen as unduly discriminatory and stigmatizing. Blood service organizations in the U.K. and the Netherlands have recently changed their deferral policies for MSM. The problem of the MSM deferral involves a conflict between fundamental rights: the right of MSM to equal treatment and the right to health of the recipients of blood and blood products. We distinguish and discuss three broad alternative options to the current categorical deferral of MSM donations: (1) completely abandoning donor selection on the basis of sexual behavior, (2) individual risk assessment of the sexual activities of each potential donor, and (3) individual risk assessment of the sexual activities of MSM only. The new U.K. policy falls within the second category, and the new Dutch policy is in the third category. We argue that each approach comes with moral costs but that the most reasonable option is different from the policies of both the U.K. and the Netherlands. (shrink)

Theory suggests that stimulus evaluations automatically evoke approach–avoidance behavior. However, the extent to which approach–avoidance behavior is triggered automatically is not yet clear. Furthermore, the nature of automatically triggered approach–avoidance behavior is controversial. We review research on two views on the type of approach–avoidance behavior that is triggered automatically (arm flexion/extension, distance change). Present evidence supports the distance-change view and corroborates the notion of an automatic pathway from evaluation to distance-change behavior. We discuss underlying mechanisms (direct stimulus–response links, outcome anticipations, (...) goals) as well as implications regarding the flexibility of the evaluation–behavior link. (shrink)

Dit boek is een uitnodiging tot en een inleiding in het filosofisch bedrijf. Filosofie begint met het inzicht dat er zoiets bestaat als een domme vraag. Die is er in twee varianten: de vraag is dom omdat er geen antwoord op kan worden gegeven of omdat ze verkeerd is gesteld. Uiteindelijk gaat filosofie over het basale onderscheid tussen domm een interessante waarheden. Zij keert zich, eventueel op een don quichoteske wijze, tegen domheid. Als filosoof krijg je de waarheid die je (...) verdient. Die waarheid vloeit voort uit de problemen die je stelt en ontwikkelt en uit de waarde van je inzichten. Wie domme vragen stelt, moet geen diepgaande en subtiele waarheden verwachten: clichés en triviale inzichten zijn de oogst. Tegen deze achtergrond gaat Roland Breeur in op de verhouding tussen tijd en bewustzijn, leven en geschiedenis, vrijheid en verbeelding. Hij schept op basis van gedachten van Nietzsche, Proust, Sartre en Deleuze een context om filosofisch over deze thema's na te denken. (shrink)

L'interrogation du phénomène esthétique est contemporaine de l'autonomisation de l'art au cours des Temps modernes et de la relativisation de sa fonction lorsqu'il n'est plus que le moyen d'exprimer la vie émotionnelle subjective. En revanche, lorsque la singularité même de l'œuvre d'art se voit mise en question au XXe siècle, ce sont les frontières séparant l'art du non-art qui deviennent évanescentes. C'est sur le fond de cet évènement que s'est déployée la réflexion de Roland Quilliot, que les contributions de (...) ce recueil se proposent de poursuivre. Celles-ci reviennent sur la notion d'image puis sur la manière dont elle se déploie du côté de la littérature comme des arts plastiques y compris du cinéma. Le second temps du recueil s'inscrit, lui, dans le cadre d'une réflexion relative à la crise de l'art moderne, en suggérant aussi que le phénomène esthétique demande à être considéré dans un cadre moral et anthropologique bien plus englobant. (shrink)

Das sinnvolle Leben ist nicht nur in der gegenwärtigen Philosophie wieder verstärkt ein Thema, sondern auch in Psychiatrie und Psychotherapie. Bereits seit langer Zeit jedoch spielt es eine zentrale Rolle in der Existenzanalyse und Logotherapie, die der Psychiater Viktor E. Frankl entwickelt hat. Frankls eigenständige Sinntheorie wird in der gegenwärtigen philosophischen Sinndebatte allerdings weitestgehend ignoriert. Das Ziel dieses Artikels ist es, diesen Zustand zu beenden und die heutige philosophische Sinndebatte mit Frankl ins Gespräch zu bringen. Einerseits geht es darum, Frankls (...) Sinntheorie im Lichte der philosophischen Sinndebatte zu verstehen und zu bewerten: Was für eine Art von Sinntheorie vertritt er? Wie ist sie einzuordnen? Wie steht es um ihre innere Kohärenz, die Plausibilität seiner sinntheoretischen Überzeugungen und die Qualität ihrer Begründung? Andererseits soll geprüft werden, inwiefern Frankls Ansatz die gegenwärtige philosophische Sinndiskussion voranbringen kann: Gibt es bei ihm theoretische Elemente, die in der Philosophie zu wenig Beachtung finden? Kann er der philosophischen Sinntheorie wichtige Impulse geben? Die Analyse folgt in ihrer Struktur wesentlichen Elementen der Frankl’schen Sinntheorie, von den grundlegenden formalen und metaethischen Aspekten hin zu inhaltlichen Bestimmungen des Sinns und dem individuellen Umgang mit ihm: Zunächst wird die zentrale Bedeutung des Sinns für das menschliche Leben thematisiert, dann Fragen nach der metaethischen Einordnung, nämlich nach der subjektivistischen oder objektivistischen Ausrichtung sowie der Rolle des Supernaturalismus. Dann stehen mit der Selbsttranszendenz und dem Wertebezug sowie den drei Wertkategorien wesentliche Elemente der Sinnkonstituierung im Fokus der Betrachtung. Die Ergebnisse werden im Schlusskapitel zusammengefasst. Es zeigt sich, dass der theoretische Austausch in beide Richtungen fruchtbar sein kann, Frankls Denken allerdings auch einige Hindernisse bereithält. Sein Ansatz entpuppt sich mit seinem objektivistischen Charakter und der zentralen Rolle von Selbsttranszendenz und Wertbezug als an die heutige Sinndiskussion gut anschlussfähig, seine oftmals fehlenden Begründungen hingegen als gravierender methodischer Makel, bei dem eine Orientierung an modernen philosophischen Standards wünschenswert wäre. Wiederholt entsteht der Eindruck, dass seine Sinntheorie maßgeblich durch sein praktisches, therapeutisches Interesse geprägt ist. Einigen seiner Theoreme wird das Potential zugesprochen, die philosophische Sinntheorie bereichern zu können: Das sind die Situativität und Individualität des Sinns sowie die Gegebenheit der Sinnmöglichkeiten und die Verantwortung für ihre Verwirklichung. (shrink)

This article’s aim is to understand if and how the efforts to accumulate and organize clinical data transformed the regulation of pharmaceutical care. The authors analyze how the employment of databases by collectives of physicians and researchers shape both clinical and policy practice—and thereby reshape the relation between clinical work and policy. Since the late 1990s, Dutch government has supported the development of clinical databases for specific expensive medicines to gain oversight about actual medicine use. To be able to produce (...) evidence for appropriate medicine use, the collectives set regulations in clinical practice. These internal regulations provide a framework for establishing “appropriate medicine use”, steering reimbursement decisions. However, internal regulation and policy rules differ in how quickly they can change. While the employment of databases in clinical practices results in a constant adjustment of the protocols, policy makers require the databases to provide for static moments of “proven appropriate medicine use” in order to account for and define a fixed and closed formulary. Subsequently, the employment of the databases did not deliver on the promise of oversight and control due to different clinical and policy requirements. Nevertheless, the databases did stimulate appropriate medicine use and reimbursement in clinical practice. (shrink)

Serious incident investigations—often conducted by means of Root Cause Analysis methodologies—are increasingly seen as platforms to learn from multiple perspectives and experiences: professionals, patients and their families alike. Underlying this principle of inclusiveness is the idea that healthcare staff and service users hold unique and valuable knowledge that can inform learning, as well as the notion that learning is a social process that involves people actively reflecting on shared knowledge. Despite initiatives to facilitate inclusiveness, research shows that embracing and learning (...) from diverse perspectives is difficult. Using the concept of ‘epistemic injustice’, pointing at practices of someone’s knowledge being unjustly disqualified or devalued, we analyze the way incident investigations are organized and executed with the aim to understand why it is difficult to embrace and learn from the multiple perspectives voiced in incident investigations. We draw from 73 semi-structured interviews with healthcare leaders, managers, healthcare professionals, incident investigators and inspectors, document analyses and ethnographic observations. Our analysis identified several structures in the incident investigation process, that can promote or hinder an actor’s epistemic contribution in the process of incident investigations. Rather than repeat calls to ‘involve more’ and ‘listen better’, we encourage policy makers to be mindful of and address the structures that can cause epistemic injustice. This can improve the outcome of incident investigations and can help to do justice to the lived experiences of the involved actors in the aftermath of a serious incident. (shrink)

"I define the Neutral as that which outplays the paradigm, or rather I call Neutral everything that baffles paradigm." With these words, Roland Barthes describes a concept that profoundly shaped his work and was the subject of a landmark series of lectures delivered in 1978 at the Collège de France, just two years before his death. Not published in France until 2002, and appearing in English for the first time, these creative and engaging lectures deepen our understanding of (...) class='Hi'>Roland Barthes's intellectual itinerary and reveal his distinctive style as thinker and teacher. The Neutral (_le neutre_), as Barthes describes it, escapes or undoes the paradigmatic binary oppositions that structure and produce meaning in Western thought and discourse. These binaries are found in all aspects of human society ranging from language to sexuality to politics. For Barthes, the attempt to deconstruct or escape from these binaries has profound ethical, philosophical, and linguistic implications. _The Neutral_ is comprised of the prewritten texts from which Barthes lectured and centers around 23 "figures," also referred to as "traits" or "twinklings," that are possible embodiments of the Neutral (sleep, silence, tact, etc.) or of the anti-Neutral (anger, arrogance, conflict, etc.). His lectures draw on a diverse set of authors and intellectual traditions, including Lao-tzu, Tolstoy, German mysticism, classical philosophy, Rousseau, Baudelaire, Walter Benjamin, and John Cage. Barthes's idiosyncratic approach to his subjects gives the lectures a playful, personal, and even joyous quality that enhances his rich insights. In addition to his reflections on a variety of literary and scholarly works, Barthes's personal convictions and the events of his life shaped the course and content of the lectures. Most prominently, as Barthes admits, the recent death of his mother and the idea of mourning shape several of his lectures. (shrink)

Comme Descartes, Malebranche réduit le concept de la stupidité à celui de l’erreur. Mais il y introduit une notion qui déborde le cadre cartésien, celle de ténèbres. L’âme ou le cogito n’est pas une idée claire et distincte, mais un « sentiment intérieur ». C’est de ces ténèbres que remontent les confusions qui caractérisent la bêtise : notre âme n’est que pure modification de soi qui dans sa dynamique auto-affective emporte avec elle les distinctions fondamentales autour desquelles s’établissent aussi bien (...) la connaissance que l’expérience que nous acquérons des choses hors de nous. Cette âme de ténèbres et de confusion est ainsi la source des erreurs répandues par ces philosophes stupides qui confondent corps et âme, objets et extériorité, matière et étendue. (shrink)

Definition of the problem: Contemporary bioethics as an academic discipline mainly focuses on moral questions – according to its articulated self-concept and the explicit arguments in most areas of bioethical reflection. Concepts and theories of the good life are hardly considered. Arguments: In reality the ‘good life’ plays a much more important role than it is assumed, but mostly only in an implicit way. The article demonstrates this by referencing three selected fields of bioethical discussion. Hence the article argues that (...) bioethics should turn the ‘good life’ into an issue of intense, explicit and systematic consideration. Furthermore, the article provides an initial answer to the questions as to why the ‘good life’ has been marginalized within bioethics up to this point and which function it can assume in future bioethical reflection. Conclusion: The ‘good life’ is the blind spot of bioethics. A more intensive and systematic consideration of the ‘good life’ is a challenge for contemporary and future bioethics. (shrink)

Roland Barthes, whose centenary falls in 2015, was a restless, protean thinker. A constant innovator, often as a daring smuggler of ideas from one discipline to another, he first gained an audience with his pithy essays on mass culture and then went on to produce some of the most suggestive and stimulating cultural criticism of the late twentieth century, including Empire of Signs, The Pleasure of the Text, and Camera Lucida. In 1976, this one time structuralist outsider was elected (...) to a chair at France's preeminent College de France, where he chose to style himself as professor of literary semiology until his death in 1980. The greater part of Barthes's published writings have been available to a French audience since 2002, but here, translator Chris Turner presents a collection of essays, interviews, prefaces, book reviews, and other journalistic material for the first time in English. Divided into five themed volumes, readers are presented in volume one, 'A Very Fine Gift' and Other Writings on Theory, with Barthes's attempts to frame his lifelong curiosities in theoretical form, from his early musings on the sociology of literature through his high period of structuralism to his later reflections on Derrida. (shrink)

Descartes is often presented as the "father" of modern subjectivity, because of his identification of thinking and being (cogito ergo sum).However, the autonomy of the cogito rests for its validation on the idea of the infinite. Consequently, what is the relation between the subject and that idea? This article tries to elucidate the complex role of an idea which, as Descartes himself seemed to admit, is very ambiguous, being "cognoscibilis et effabilis" and "ineffabilis et incomprehensibilis" at the same time. This (...) ambiguity, as is argued, determines the very nature of the "Cartesian subject" as such, and that Descartes describes as being "something intermediate between God and nothingness". What is this "between"? (shrink)

Après un premier volume, A l'Orient de Michel Henry (2014), cet ensemble de textes poursuit la quête d'une définition de la vérité comprise comme subjectivité vivante, comme cette épreuve de soi qui conditionne et transite ensuite l'ensemble des expériences et des savoirs qui sont les nôtres. Il apparaîtra, ce faisant, le caractère éminemment concret des catégories mises en oeuvre par Michel Henry et comment elles peuvent s'appliquer à de nombreux domaines d'existence, étant capables d'en rendre compte avec cette pertinence et (...) cette puissance explicative que permet seul leur ancrage dans le fondement vivant qui les informe secrètement sous l'apparence des choses. (shrink)

La nécessité, en milieu académique, de toujours transcrire aussi complètement et systématiquement que possible les détails bibliographiques des travaux d'un auteur ou des ouvrages se rapportant à lui n'est pas à démontrer. Comment donc soutenir qu'on puisse omettre le nom des maisons d'édition? Le choix d'un éditeur, par un auteur, est aussi important que le choix d'un titre. Et pour le lecteur, c'est une circonstance qui donne à penser! Dans la littérature teilhardienne il existe en effet des cas qui donnent (...) beaucoup à penser. Avant de présenter un répertoire sommaire des bibliographies, biographies et lexiques teilhardiens, nous voudrions attirer l'attention sur le problème de valeur sémantique soulevé par l'existence de deux éditions anglaises d'une même traduction du Milieu Divin. Car les expressions sémantiques, tout autant que les idées, ont leurs conséquences. (shrink)

The heart of Book Two of De Iibero arbitrio is devoted to a lengthy argument that concludes that God is and is truly and sovereignly. This argument rests upon two crucial principia that have been called the principles of subordination and participation. An examination of their function in the argument reveals that Augustine could hardly have thought that he had produced a demonstration of God’s existence.